个人简介
工作经历
2024-01至今：副教授，中山成人直播 ，成人直播
2022-08至2024-01：特聘副研究员，中山成人直播 ，成人直播
2020-08至2022-08：博士后，中山成人直播 ，成人直播
教育经历
2015-09至2020-06：博士，外科学，附属第一医院，成人直播
2010-09至2015-06：本科，临床医学，中山成人直播 ，成人直播
学术成果
学术论文
- Liu C#, Peng H#, Yu J#, Luo P#, Xiong C, Chen H, Fan H, Ma Y, Ou W, Zhang S, Yang C, Zhao L, Zhang Y, Guo X, Ke Q, Wang T, Deng C, Li W, Xiang AP*, Xia K*. Impaired ketogenesis in Leydig Cells drives testicular aging. Nature Communications. 2025
Xia K#, Wang F#, Lai X#, Dong L#, Luo P, Zhang S, Yang C, Chen H, Ma Y, Huang W, Ou W, Li Y, Feng X, Yang B, Liu C, Lei Z, Tu X, Ke Q, Mao FF, Deng C*, Xiang AP*. AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failure. Cell Reports Medicine. 2022
- Xia K#, Wang F#, Tan Z#, Zhang S#, Lai X, Ou W, Yang C, Chen H, Peng H, Luo P, Hu A, Tu X, Wang T, Ke Q, Deng C*, Xiang AP*. Precise correction of Lhcgr mutation in stem Leydig cells by prime editing rescues hereditary primary hypogonadism in mice. Advanced Science. 2023
Chen H#, Xia K#, Huang W#, Li H, Wang C, Ma Y, Chen J, Luo P, Zheng S, Wang J, Wang Y, Dong L, Tan Z, Lai X, Mao FF, Li W, Liang X, Wang T, Xiang AP, Qiong K*.Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates. Cell Discovery. 2021
Xia K#, Chen H#, Wang J#, Feng X#, Gao Y, Wang Y, Deng R, Wu C, Luo P, Zhang M, Wang C, Zhang Y, Zhang Y, Liu G, Tu X, Sun X, Li W, Ke Q*, Deng C*, Xiang AP*.Restorative functions of autologous stem Leydig cell transplantation in a testosterone-deficient non-human primate model. Theranostics. 2020
- Xia K#, Luo P#, Yu J#, He S#, Dong L, Gao F, Chen X, Ye Y, Gao Y, Ma Y, Yang C, Zhang Y, Yang Q, Han D, Feng X, Wan Z, Cai H, Ke Q, Wang T, Li W, Tu X, Sun X, Deng C*, Xiang AP*. Single-cell RNA Sequencing Reveals Transcriptomic Landscape and Potential Targets for Human Testicular Ageing. Human Reproduction.2024
Xia K, Ma Y, Feng X, Deng R, Ke Q, Xiang AP*, Deng C*. Endosialin defines human stem Leydig cells with regenerative potential. Human Reproduction. 2020
- Zhang S#, Yang B#, Shen X#, Chen H#, Wang F, Tan Z, Ou W, Yang C, Liu C, Peng H, Luo P, Lei Z, Yan S, Wang T, Ke Q, Deng C, Xiang AP*, Xia K*.AAV-mediated gene therapy restores natural fertility and improves physical function in the Lhcgr-deficient mouse model of Leydig cell failure. Cell Proliferation. 2024
- Luo P#, Chen X#, Gao F, Xiang AP, Deng C, Xia K*, Gao Y*. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Rescue Testicular Aging. Biomedicines.2024
- Xia K, Yu J, Liu G, Chen H, Ge R, Deng C. Editorial: Aging and male hypogonadism. Frontiers in Endocrinology. 2023
- Su Z#, Liu Z#, Lei W#, Xia K#, Xiao A, Hu Z, Zhou M, Zhu F, Tian J, Yang M, Wang D, Xiang AP, Nie J.Hyperhomocysteinemia lowers serum testosterone concentration via impairing testosterone production in Leydig cells. Cell Biology and Toxicology. 2023
- Xie Q#, Cao H#, Xia K#, Gao Y*, Deng C*. Prenatal DEHP Exposure Induces Premature Testicular Aging by Promoting Leydig Cell Senescence through the MAPK Signaling Pathways. Advanced Biology. 2023
Xie Q#, Luo P#, Xia K#, Li Z#, Xu Z*, Su C*, Deng C*. 46,XY disorders of sex development: the use of NGS for prevalent variants. Human Genetics. 2022
Feng X#, Xia K#, Ke Q#, Deng R, Zhuang J, Wan Z, Luo P, Wang F, Zang Z, Sun X, Xiang AP, Tu X*, Gao Y*, Deng C*. Transplantation of encapsulated human Leydig-like cells: A novel option for the treatment of testosterone deficiency. Molecular and Cellular Endocrinology.2021
Luo P#, Feng X#, Deng R#, Wang F, Zhang Y, Li X, Zhang M, Wan Z, Xiang AP, Xia K*, Gao Y*, Deng C*. An autofluorescence-based isolation of Leydig cells for testosterone deficiency treatment. Molecular and Cellular Endocrinology. 2021
科研项目
主持项目
1. 国家自然科学基金面上项目，2024-01至2027-12，49万
2. 国家自然科学基金青年项目，2022-01至2024-12，30万
3. 中国博士后基金面上项目，2021-10至2022-07，8万
4. 广东省自然科学基金面上项目，2022-01至2024-12，10万
5. 广州市基础与应用基础研究“启航”类项目，2024-01至2025-12，5万
6. 成人直播
高校基本科研业务费，2022-01至2022-12，8.53万
